As a German engineering company for medical devices we started in 1986 our first production of micro-needles (in the range of 0.15 to 0.23 mm in diameter) for tissue implants. In 1999 we continued with our research for micro-needle therapies. In 2000 we patented the Dermaroller®. With this unique tool tiring and time consuming single-needle scar therapies became obsolete. Numerous clinical studies and research confirmed our thesis that very slim and non-traumatic micro-needles in the range of 0.5 to 1.5 mm in length stimulate new collagen and capillary formation in the skin. We developed a minimal invasive and non-ablative needling technology without any skin lesion. In close cooperation with plastic surgeons we gradually improved our devices, and today the Dermaroller® is the most versatile and effective medical device for scar treatment of any form, depressed acne scars and hypertrophic scars after operations or accidents. Compared with any other conventional therapies, the Dermaroller® produces visible, lasting and impressive scar improvement.
It is a well researched fact that delivery of drugs and vaccines direct through the upper skin layer (epidermis) stimulate a much higher therapeutic and immune response compared with normal hypodermic needles in muscle tissue. This in return was the starting point for the research for new drugs and DNA-vaccines that are applied right into the upper skin layer, not deeper than 0.2 to 0.3 mm. This way of drug and vaccine delivery is painless, scar-free, and reduces possible systemic side effects to a minimum. Numerous laboratories started to develop transdermal delivery devices made from silicon and biodegradable plastic needles and arrays. We took on that challenge, and based on our technical knowledge in handling fine steel needles we started to concentrate on micro devices for transdermal delivery arrays. Laboratory tests confirmed the efficasy and superiority of our micro-steel needles, and encouraged us to start commercial sales of transdermal delivery devices beginning 2012.
Collagen Induction Therapy
The Collagen-Induction-Therapy (CIT) by micro-needling the skin requires special medical Dermarollers and medical knowledge. As human skin has an average thickness of 1.5 mm, Dermaroller needle lengths range from 0.15 to 1.5 mm. Any longer needles - often offered by copiers of the Original - are contraindicated! Needles longer than 0.25 mm cause pain and require a pre-anaesthetisation of the skin. In order to avoid infections and other unpleasant experiences, a medical procedure should always be performed in a clinical environment!
Important! The induction of body's own new collagen is a medical procedure and should only be performed by trained and licensed skin care professionals.
Mechanism of Action in Micro-Needling
In micro-needling we simply utilise the body self-healing mechanisms. It reacts to the intrusion of micro-needles like it would react to any other skin penetrating object. But the difference is the size of the object - the micro-needle. The intrusion of tiny surgical needles (provided they are professionally designed) is sensed by skin nerve receptors as an injury stimulus. But the needles are so fine and thin that tissue damage is unlikely. The skin integrity actually stays intact. However, this "nerve-stimulus", transported by electrical signals, triggers the cascade of the healing process. Skin cells, in a radius of 1 to 2 mm around the pricking channel, release growth signals to undifferentiated cells. These signals in return stimulate the proliferation of new cells, e.g. fibroblasts to transform into collagen- and elastin fibres. The task of fibroblasts is, to migrate to the point of intrusion for wound closure. And here comes the trick: The pricking channels, caused by the micro-needles, close very quickly and no tissue lesion can be detected, and none has to be repaired. The transformation for wound repair cells (e.g. fibroblasts and others) is an automatic process - like a one-way road. Their final mission is to transform into collagen fibres. They integrate into the existing collagen formation in the upper dermis. This new fibre formation - in terms of many hundred percent - thickens the skin and fills former atrophic scars. As single needle prick is not worth mentioning. But if thousands of microscopic small needle-pricks are set, the induced collagen formation becomes confluent and forms a new collagen layer. This body reaction is called neo-collagenesis.
In addition, the inner cells that coat our vessels (endothelial cells), and in particular these of our capillaries, are also stimulated to proliferate. They react to this stimulation by sprouting out new capillaries that in return results in more and better blood supply of the skin. This reaction is called neo-angiogenesis.
Roll away the years
Many Hollywood stars are having Dermaroller treatment to achieve a younger looking, glowing skin. Jennifer Aniston reportedly uses Dermaroller Therapy to give her skin a fresh faced, natural look. Angelina Jolie is reported to have tried Dermaroller Therapy after being introduced to it by husband Brad Pitt, who is himself thought to have undergone a series of treatments to combat acne scars.
Dermaroller in the press [PDF, 1,939k]
The first signs of aging skin are in general the formation of fine lines, especially around the eyes and upper lip. The scale layers of the epidermis become thinner and harder and its previous transparency starts to fade. The dermis is losing its elasticity by degrading elastin- and hardening collagen fibers. The cells of the sub dermal tissue start to shrink. And in addition the skin faces a dramatic moisture loss. All these factors form the degrading process of our skin.
What can be done to stop this degradation? The answer is cell regeneration! This can be achieved with the Collagen-Induction-Therapy (CIT). The CIT is a simple procedure by microneedling the skin with the medical Dermaroller. It is absolutely effective and stimulates new collagen cells that boost your skin by remodeling the structure of demis and epidermis.
According to the individual skin condition, 1 to 3 procedures, separated by 6 to 8 weeks, are sufficient to resurface the skin. As aging continues, we recommend one refresher-CIT every year. Between the CITs and after the last one, you can support the results of the CIT by using the Home Care Dermaroller in combination with high-end peptide serums.